*Very smooth surface – less vulnerable to abrasion The coating consists of a 1:1 mixture of Paclitaxel with shellac applied to the balloon by a micro-pipetting procedure in a clean room under sterile conditions. Shellac is a natural resin composed of shellolic and alleuritic acid. Neither direct contact to shellac-coated materials nor exposure to shellac extraction products impaired HDMEC and hSMC viability and function in vitro. Jahrestagung der Deutschen Gesellschaft für Biomaterialien, 8.-, Tübingen Testing of in vitro compatibility by endothelial and smooth muscle cells. Peters K, Prinz C, Salamon A, Adam A, Stuhldreier G, Rychly J, Neumann H-G.Įvaluation of shellac as coating of intravascular devices – Shellac extraction products (24 h) Exposition of confluent HDMEC with extraction products (24 h) tumour necrosis factor α (TNFα ) as a positive control group The FREEWAY ™ 014 Bioshell coating matrix consists of a natural resin, which is EMA and FDA approved (GRAS) as food additive under E 904. The excellent film forming properties of shellac are used to coat gastric resistant tablets. Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and vivo using local drug delivery. The FREEWAY Paclitaxel-releasing PTA balloon dilatation catheter enhances a smooth re-endothelialization process. Paclitaxel does not influence non-proliferating cells as a result of cytokine and growth factor stimulation.
The endothelium cells show a better resistance to Paclitaxel than the smooth muscle cells due to the different affinity of the connective structure on the cell surface. Paclitaxel selectively inhibits the proliferation of smooth muscle cells. Paclitaxel also inhibits extracellular matrix secretion and breakdown. Paclitaxel inhibits platelet derived growth factor (PDGF) mediated vascular smooth muscle cell migration to the intima. After balloon dilatation, injuries to the arterial wall stimulate inflammatory reaction, and the excretion of growth factors occurs as an important process along with the onset of cell division and the migration of smooth muscle cells. Paclitaxel prevents restenosis by blocking proper microtubal formation, thus it inhibits cell division and migration. Ati facut deja primii pasi in invatarea limbii engleze. Cursuri Engleza nivel Intermediar Interactiv. This entry was posted in Impreuna, Informatii utile and tagged cursuri, cursuri gratis, cursuri gratis de engleza, cursuri gratis pentru limba germana.
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